Linked Life Data

6766508

Source:http://linkedlifedata.com/resource/pubmed/id/6766508

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-4-17
pubmed:abstractText
The effect of diet and Lactobacillus acidophilus supplements on fecal microflora enzyme activity was studied in humans. The bacterial enzymes that were investigated are known to catalyze reactions that may result in formation of proximal carcinogens. Compared to vegetarians, omnivores eating a "Western-type" diet had higher levels of beta-glucuronidase, nitroreductase, azoreductase, and steroid 7-alpha-dehydroxylase in their fecal microflora. Removal of red meat or addition of fiber in the form of bran or wheat germ to the diet of omnivores for 30 days had no effect on beta-glucuronidase, nitroreductase, or azoreductase activity. However, removal of red meat or addition of fiber reduced fecal steroid 7-alpha-dehydroxylase activity. The addition of viable Lactobacillus acidophilus supplements to the diet of omnivores significantly decreased fecal bacterial beta-glucuronidase and nitroreductase activities. Thirty days after Lactobacillus supplements were curtailed, fecal enzyme levels returned to normal base-line activities. These findings suggested that the metabolic activity of the fecal microflora was influenced by diet and could be altered by Lactobacillus supplements and to a lesser extent by dietary fiber.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:6766508-Adult, pubmed-meshheading:6766508-Animals, pubmed-meshheading:6766508-Azo Compounds, pubmed-meshheading:6766508-Bacteria, pubmed-meshheading:6766508-Cholic Acids, pubmed-meshheading:6766508-Diet, pubmed-meshheading:6766508-Diet, Vegetarian, pubmed-meshheading:6766508-Dietary Fiber, pubmed-meshheading:6766508-Feces, pubmed-meshheading:6766508-Female, pubmed-meshheading:6766508-Glucuronidase, pubmed-meshheading:6766508-Humans, pubmed-meshheading:6766508-Intestines, pubmed-meshheading:6766508-Lactobacillus acidophilus, pubmed-meshheading:6766508-Male, pubmed-meshheading:6766508-Meat, pubmed-meshheading:6766508-NADH, NADPH Oxidoreductases, pubmed-meshheading:6766508-Nitro Compounds, pubmed-meshheading:6766508-Oxidoreductases, pubmed-meshheading:6766508-Steroid Hydroxylases
pubmed:year
1980
pubmed:articleTitle
Effect of diet and Lactobacillus acidophilus supplements on human fecal bacterial enzymes.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.