Linked Life Data

6761183

Source:http://linkedlifedata.com/resource/pubmed/id/6761183

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-4-7
pubmed:abstractText
A rapid inhibitory effect of corticosterone upon glucose- or leucine-induced insulin release being established, steroid action upon insulin biosynthesis of rat Langerhans islets was studied as a function of time. Islet proinsulin and insulin content was reduced after two hours of incubation in presence of corticosterone (0.2 mg/l) with a 16.7 mmoles/l glucose stimulation. L (-) [4-5(3)H] leucine incorporation into proinsulin and insulin was lowered at all time (points examined: 1, 2 and 3 hours). Incorporation ratio between proinsulin and insulin remained stable, so an interaction at the proinsulin biosynthetic level may be possible. Corticosterone had no effect upon biosynthesis of other islet proteins. Our data suggest that the corticosterone inhibition of insulin biosynthesis is specific.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0338-1684
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Effect of corticosterone upon insulin biosynthesis and storage by isolated rat Langerhans islets.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't