Linked Life Data

6760566

Source:http://linkedlifedata.com/resource/pubmed/id/6760566

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1983-3-17
pubmed:abstractText
1. 14C-Captopril (50 mg/kg) administered orally to pregnant rats resulted in radioactivity passing the placental barrier into foetuses and amniotic fluid. Two hours after dosing, the mean (+/- S.E.M.) concentration of total radioactivity was 0.97 +/- 0.07 micrograms equiv. of captopril/g in foetuses and 7.8 +/- 0.54 micrograms equiv./g in maternal blood. The mean concentration of unchanged captopril at this time was 0.22 +/- 0.04 micrograms/g in foetuses and 2.4 +/- 0.27 micrograms/g in maternal blood. Results obtained by whole-body autoradiography generally were consistent with those obtained by measuring radioactivity in excised tissues. 2. Radioactivity was also found in suckling pups and in the milk of th dams. Autoradiographs of the pups showed detectable radioactivity in the brain; as no radioactivity was detectable in the brain of the dam, it appears that the blood-brain barrier was not fully developed in seven-day-old pups.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0049-8254
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
627-32
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Distribution of captopril to foetuses and milk of rats.
pubmed:publicationType
Journal Article