Linked Life Data

6757112

Source:http://linkedlifedata.com/resource/pubmed/id/6757112

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-2-25
pubmed:abstractText
Human lymphocytes are activated by cell walls or cytoplasma membranes of A-streptococci. Even in health human volunteers lymphocyte proliferation, lymphokine production and immunoglobulin synthesis is induced by high concentrations of streptococcal cell components following a pattern of polyclonal lymphocyte activation. We were interested in the special cellular requirements in this particular model. In cell separation and restitution experiments the observed B-cell activation was identified as the consequence of a primary monocyte-dependent polyclonal T-cell activation. Furthermore, lymphocyte proliferation and lymphokine production proved to be a monocyte- and T-cell-dependent process as well. Thus, lymphocyte activation induced by somatic streptococcal structures in humans depends upon a pattern of cell cooperation of mononuclear subpopulations well-known in a series of classical mitogen-induced lymphocyte activation.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0340-1162
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
187-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[Streptococcal A-induced polyclonal T-cell activation leads to a secondary functional activation of human B-cells].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't