Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1983-1-27
pubmed:abstractText
This paper reviews the literature on the role of food in the homeostatic regulation of serum and tissue gastrin levels. In general, the scientific evidence indicates that, in addition to neural and systemic factors (not reviewed here), the chemical rather than the physical characteristics of a meal play an important role in the initiation of the postprandial release of gastrin. The chemical nature of those secretory stimulants have yet to be identified, and evidence is presented that pertains to the role of dietary amino acids and amines as mediators of the gastrin secretory response to a meal. The molecular events associated with food-induced gastrin release have yet to be resolved, and ultrastructural evidence is reviewed supporting three contrasting mechanisms of hormone secretion. Morphological and kinetic studies also indicate that G-cell viability and proliferation as well as intracellular gastrin formation are dependent on the oral intake of dietary stimulants of gastrin release. Additionally, evidence is presented that suggests that food may stimulate gastrin formation both acutely and chronically by catalyzing the posttranslational conversion of a precursor molecule to the active hormone and by increasing hormone biosynthesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
243
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G429-41
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Importance of food in the regulation of gastrin release and formation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review