Linked Life Data

6755494

Source:http://linkedlifedata.com/resource/pubmed/id/6755494

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1983-1-7
pubmed:abstractText
1,3-Di(3-pyridyl)-2-propen-1-one (1) react with malononitrile in presence of ammonium acetate to afford 2-amino-3-cyano-4, 6-di(3-pyridyl)pyridine (2), which was converted to the nicotinamide derivative 3 by hydrolysis with alkali. In a similar way, 1 react with ethyl cyanoacetate to give 3-cyano-4,6-(3-pyridyl)-2-pyridone (4). Treating of 1 with hydroxylamine hydrochloride afforded the oxime 5 which upon reaction with alkyl- or aryl-isocyanates gave the oxime carbamates 6. Reaction of thiourea and hydrazines with 1 gave the thiopyrimidine 7 and the pyrazolines 8, respectively. The structure of the obtained compounds was confirmed according to their IR and UV spectra. The antimicrobial activity of the synthesized compounds against several microorganisms is presented.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0031-7144
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
551-3
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Azachalcones. Part 2: Reactions of 3,3-diazachalcones.
pubmed:publicationType
Journal Article