Linked Life Data

6753242

Source:http://linkedlifedata.com/resource/pubmed/id/6753242

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-12-21
pubmed:abstractText
Aeromonas hydrophila produces two hemolysins and an enterotoxin during growth. Enterotoxin, separated from the hemolysins, gave positive reactions in the rabbit intestinal loop test, the rabbit skin test and the adrenal Y1 cell test. Neutralization experiments in the rabbit loop, rabbit skin and Y1 cell tests failed to demonstrate any immunological relationship between Aeromonas enterotoxin and cholera toxin or Escherichia coli heat-labile enterotoxin. Prior incubation of Aeromonas enterotoxin with gangliosides did not inhibit the positive test results in these systems. A co-agglutination test with antiserum to purified cholera toxin was negative for Aeromonas enterotoxin, which therefore seems to be immunologically distinct from cholera toxin. The Aeromonas enterotoxin induced steroid secretion in adrenal Y1 cells and increased the intracellular cyclic adenosine monophosphate (cAMP) content of Y1 cells as well as of rabbit intestinal epithelial cells. It thus seems to act via the adenylate cyclase-cAMP pathway and should be classified as a cytotonic enterotoxin according to the classification of Keusch and Donta (1975).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0041-0101
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
787-94
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Cytotonic enterotoxin from Aeromonas hydrophila.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't