Linked Life Data

6748651

Source:http://linkedlifedata.com/resource/pubmed/id/6748651

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6A
pubmed:dateCreated
1984-8-29
pubmed:abstractText
The dihydrotestosterone (DHT)-sustained normal pubertal development of the guinea pig seminal vesicle epithelium proved to be highly reversible in that 4 weeks after cessation of hormone treatment there were significant reductions in epithelial wet weight, DNA content, and collagen content. In contrast, the DHT-induced prepubertal development of smooth muscle DNA and collagen contents were not significantly reduced following hormone withdrawal. In adult animals treated daily with DHT for 4 weeks, there was an increase in collagen content of approx 80% above either castrate or normal controls, which also proved to be irreversible. These findings indicate that the autophagic mechanisms, which are activated upon withdrawal of the androgenic stimulus and serve to degrade epithelial cells and the associated collagenous matrices, are not operant in the smooth muscle of the organ.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-4731
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1361-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Irreversible androgen induced growth in seminal vesicle smooth muscle.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.