Linked Life Data

6743194

Source:http://linkedlifedata.com/resource/pubmed/id/6743194

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-8-2
pubmed:abstractText
The inotropic action of ouabain on isolated perfused hearts of rat, guinea-pig, and cat was studied over a wide concentration range (10(-12)-5 X 10(-3) M). In all three species used, the positive inotropic effect (PIE) of ouabain appeared to be biphasic in character. However, there was a remarkable difference in the course of the logdose-response curves of ouabain on guinea-pig and cat heart as compared with than on rat heart. The first two species showed, at very low concentrations of ouabain (guinea-pig heart: 10(-9) M and cat heart: 10(-10) M), a typical bell-shaped increase in cardiac contractile activity, while at higher concentrations (10(-8)-10(-6) M and 10(-9)-10(-7) M, respectively) the normally observed S-shaped increase in contractile activity occurred. On the contrary, rat hearts showed a flat S-curve between 10(-8) and 10(-6) M and a steep one between 10(-6) and 10(-4) M of ouabain. In order to explain the biphasic action of ouabain a hypothetical model for the mechanism(s) of action of ouabain is discussed. Mathematical description of this model is based on the existence of two different receptor-types for ouabain. It is suggested that sarcolemma-bound calcium may play an important role in both mechanisms of inotropic action of ouabain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-8428
pubmed:author
pubmed:issnType
Print
pubmed:volume
79 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
102-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Biphasic positive inotropic actions of ouabain on rat, guinea-pig and cat heart: a mathematical description.
pubmed:publicationType
Journal Article