Linked Life Data

6742463

Source:http://linkedlifedata.com/resource/pubmed/id/6742463

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-8-3
pubmed:abstractText
Based on recent findings indicating suppression of lymphocytic functions by seminal plasma (SP) we tested the effects of SP from men with normo- and oligozoospermia (n = 7, each) on the generation of luminol-enhanced chemiluminescence (CL) of polymorphonuclear leukocytes (PMN) and monocytes (M psi) stimulated in vitro with zymosan. We found a complete suppression of CL of PMN and M psi by undiluted SP's, 1,000-fold dilutions still induced greater than or equal to 20 percent inhibition. There was no difference between normo- and oligozoospermic men in inhibition of CL both with PMN and M psi. Protein concentrations of SP's were closely the same; all SP were free of the complement components C4 and C3c. After dialysis of SP the inhibition of PMN - and M psi - generated CL was no longer present. Our results demonstrate that SP exerts extremely potent inhibition of cells mediating nonspecific defense and/or antigen presentation. The inhibitor appears to be of low molecular weight. These findings may be important for infections acquired by the genital tract and may provide an explanation for the immunotolerance of spermatozoa in the female reproductive system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0303-4569
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
124-8
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:articleTitle
Seminal plasma-induced suppression of the respiratory burst of polymorphonuclear leukocytes and monocytes.
pubmed:publicationType
Journal Article