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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1984-7-27
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pubmed:abstractText |
In a randomised cross-over trial, midazolam, a new water soluble benzodiazepine was compared with the conventional diazepam preparation (Valium) in 34 patients aged 16-45 years who were undergoing outpatient conservation dentistry. Midazolam hydrochloride (0.17 mg/kg) was virtually free of venous complications and showed advantages over diazepam (0.32 mg/kg) in providing a faster onset of action, higher incidence of amnesia and more rapid recovery. Midazolam produced a higher incidence of respiratory side effects hiccough (17.6% compared with 2.9%), brief apnoea following induction (11.8% compared with 5.8%), and airway obstruction during maintenance (8.8% compared with 0%). These may be related to the greater potency of midazolam as suggested by the smaller total dose required. Cardiovascular changes and operating conditions were similar.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0003-2409
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
39
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
589-93
|
pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6742394-Adolescent,
pubmed-meshheading:6742394-Adult,
pubmed-meshheading:6742394-Benzodiazepines,
pubmed-meshheading:6742394-Dentistry,
pubmed-meshheading:6742394-Diazepam,
pubmed-meshheading:6742394-Female,
pubmed-meshheading:6742394-Humans,
pubmed-meshheading:6742394-Hypnotics and Sedatives,
pubmed-meshheading:6742394-Male,
pubmed-meshheading:6742394-Midazolam,
pubmed-meshheading:6742394-Middle Aged,
pubmed-meshheading:6742394-Random Allocation
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pubmed:year |
1984
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pubmed:articleTitle |
A comparison of midazolam and diazepam for intravenous sedation in dentistry.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|