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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1984-8-13
|
| pubmed:abstractText |
The stereoisomer form of timolol used in the treatment of glaucoma is l-timolol. Although d-timolol is a less potent beta-adrenergic receptor blocker than l-timolol, several laboratory studies have found that d-timolol has ocular hypotensive effects. Thus, d-timolol may be a useful therapeutic agent for glaucoma that has fewer systemic side effects than l-timolol. We conducted a randomized, double-masked, single-drop study of the effects of d-timolol and placebo on intraocular pressure in 34 patients with ocular hypertension. d-Timolol significantly lowered intraocular pressure for the six-hour duration of the study. No patients receiving the drug reported subjective side effects. There was no change in visual acuity, pupil size, or results of external ocular or slit-lamp examinations during the study. No changes in pulse rate or blood pressure were attributable to the drug.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0002-9394
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
98
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
73-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6742081-Administration, Topical,
pubmed-meshheading:6742081-Adult,
pubmed-meshheading:6742081-Aged,
pubmed-meshheading:6742081-Blood Pressure,
pubmed-meshheading:6742081-Double-Blind Method,
pubmed-meshheading:6742081-Drug Evaluation,
pubmed-meshheading:6742081-Eye,
pubmed-meshheading:6742081-Female,
pubmed-meshheading:6742081-Heart Rate,
pubmed-meshheading:6742081-Humans,
pubmed-meshheading:6742081-Intraocular Pressure,
pubmed-meshheading:6742081-Male,
pubmed-meshheading:6742081-Middle Aged,
pubmed-meshheading:6742081-Ocular Hypertension,
pubmed-meshheading:6742081-Ophthalmic Solutions,
pubmed-meshheading:6742081-Pupil,
pubmed-meshheading:6742081-Random Allocation,
pubmed-meshheading:6742081-Stereoisomerism,
pubmed-meshheading:6742081-Timolol,
pubmed-meshheading:6742081-Visual Acuity
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
The effect of d-timolol on intraocular pressure in patients with ocular hypertension.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|