Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1984-8-2
pubmed:abstractText
We previously showed that 1 hr exposures to submicrometer sulfuric acid (H2SO4) aerosol at 100 and 1000 micrograms/m3 altered the bronchial mucociliary clearance of monodisperse 7.6 micron MMAD 99mTc-labelled ferric oxide (Fe2O3) in healthy, nonsmoking humans. The 7.6 micron particles were primarily deposited in the larger bronchial airways, where submicrometer H2SO4 has very little deposition. To determine the extent that submicrometer H2SO4 aerosol affects clearance from the more distal ciliated airways, we measured the clearance of a monodisperse 4.2 micron MMAD Fe2O3 aerosol in eight other healthy nonsmoking subjects. A greater fraction of 4.2 micron particles deposited in distal conductive airways. Bronchial mucociliary clearance was slower following 1 h nasal H2SO4 inhalations at 100, 300 and 1000 micrograms/m3 than after sham exposures, while mucociliary transport rates within the trachea and indices of respiratory mechanics were unchanged. A comparison of the effects of 1 h exposures at 100 micrograms/m3 on the clearance of 7.6 and 4.2 micron particles suggests greater physiological response in distal ciliated airways than in larger central airways.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-8894
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
285-92
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:6741776-Adult, pubmed-meshheading:6741776-Aerosols, pubmed-meshheading:6741776-Airway Resistance, pubmed-meshheading:6741776-Bronchi, pubmed-meshheading:6741776-Cilia, pubmed-meshheading:6741776-Dose-Response Relationship, Drug, pubmed-meshheading:6741776-Female, pubmed-meshheading:6741776-Ferric Compounds, pubmed-meshheading:6741776-Forced Expiratory Volume, pubmed-meshheading:6741776-Humans, pubmed-meshheading:6741776-Iron, pubmed-meshheading:6741776-Male, pubmed-meshheading:6741776-Middle Aged, pubmed-meshheading:6741776-Mucus, pubmed-meshheading:6741776-Particle Size, pubmed-meshheading:6741776-Respiration, pubmed-meshheading:6741776-Respiratory Physiological Phenomena, pubmed-meshheading:6741776-Respiratory System, pubmed-meshheading:6741776-Sulfuric Acids, pubmed-meshheading:6741776-Trachea
pubmed:year
1984
pubmed:articleTitle
Dose-dependent effects of submicrometer sulfuric acid aerosol on particle clearance from ciliated human lung airways.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't