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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1984-7-27
|
| pubmed:abstractText |
Although the antiarrhythmic aspect of amiodarone has been extensively studied, its effects on His-Purkinje system conduction and refractoriness have not been systematically investigated in human beings. In 24 patients, anterograde His-Purkinje system conduction (HV intervals) and variables of His-Purkinje system refractoriness using the ventricular extrastimulus (V2) technique were analyzed before and after long-term therapy with amiodarone. The mean duration of amiodarone therapy at the time of repeat study was 16.2 +/- 7.7 weeks (range 11 to 42). The anterograde His-Purkinje system conduction time (HV interval) measured 49.6 +/- 9.5 ms (range 40 to 80) before and 60.6 +/- 10.7 ms (range 45 to 90) after amiodarone (p less than 0.005). During retrograde refractory period studies, the longest V1V2 interval at which a retrograde His bundle potential (H2) emerged from the V2 electrogram (relative refractory period of the His-Purkinje system) was consistently longer after amiodarone as compared with the control period (376.4 +/- 46.6 versus 318.8 +/- 33.1 ms, p less than 0.005). Similarly, the shortest and longest His-Purkinje system conduction times ( V2H2 interval) at comparable V1V2 intervals were uniformly and significantly prolonged after administration of the drug. Amiodarone also abolished macroreentry in the His-Purkinje system in six of the nine patients who showed such reentry during the control period. The effective refractory period of the ventricular myocardium was also increased from a mean of 227.1 +/- 13.9 to 259.2 +/- 20.2 ms (p less than 0.005) in this series of patients.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0735-1097
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
105-10
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| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6736436-Adult,
pubmed-meshheading:6736436-Aged,
pubmed-meshheading:6736436-Amiodarone,
pubmed-meshheading:6736436-Arrhythmias, Cardiac,
pubmed-meshheading:6736436-Benzofurans,
pubmed-meshheading:6736436-Bundle of His,
pubmed-meshheading:6736436-Cardiac Pacing, Artificial,
pubmed-meshheading:6736436-Electrocardiography,
pubmed-meshheading:6736436-Female,
pubmed-meshheading:6736436-Heart Conduction System,
pubmed-meshheading:6736436-Heart Rate,
pubmed-meshheading:6736436-Heart Ventricles,
pubmed-meshheading:6736436-Humans,
pubmed-meshheading:6736436-Male,
pubmed-meshheading:6736436-Middle Aged,
pubmed-meshheading:6736436-Purkinje Fibers,
pubmed-meshheading:6736436-Tachycardia
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Effect of amiodarone on conduction and refractoriness of the His-Purkinje system in the human heart.
|
| pubmed:publicationType |
Journal Article
|