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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1984-7-27
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pubmed:abstractText |
The effect of impaired liver function on the pharmacokinetics of cimetidine was studied in 8 patients with advanced cirrhosis given single doses of 100 mg i.v. and 400 mg p.o. on separate days. Compared to a control group of 10 healthy volunteers, the total renal and nonrenal clearance was significantly reduced in the cirrhotic patients; (total plasma clearance mean +/- SD) 356 +/- 181 vs 789 +/- 262 ml/min (p less than 0.01); renal clearance (Clr) 296 +/- 100 vs 588 +/- 181 ml/min (p less than 0.01) and nonrenal clearance ( Clnr ) 97 +/- 111 vs 205 +/- 89 ml/min (p less than 0.05). Compared to published results for age-matched ulcer patients, both total and nonrenal clearance were lower whereas renal clearance was within the reported normal range. A significant reduction in volume of distribution (Vd beta) was found, from 2.1 +/- 0.1 l/kg in controls to 1.0 +/- 0.4 l/kg, and in the patient group there was a significant correlation between Vd beta and total plasma clearance (r = 0.72, p less than 0.05). Volume of distribution in steady state (Vdss) did not differ from published results in age-matched controls. No significant change in half-life was found. Bioavailability, estimated by AUC-measurement, showed considerable patient variability (21-143%), with a mean of 70 +/- 39%. This was lower than in the controls. In contrast, measurement of urinary excretion showed higher bioavailability in the patients (66 +/- 23 vs 51 +/- 8%). No correlation was found between any of the kinetic parameters and the clinical and laboratory data.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0031-6970
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
347-55
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6734697-Administration, Oral,
pubmed-meshheading:6734697-Adult,
pubmed-meshheading:6734697-Aged,
pubmed-meshheading:6734697-Biological Availability,
pubmed-meshheading:6734697-Cimetidine,
pubmed-meshheading:6734697-Creatinine,
pubmed-meshheading:6734697-Female,
pubmed-meshheading:6734697-Half-Life,
pubmed-meshheading:6734697-Humans,
pubmed-meshheading:6734697-Injections, Intravenous,
pubmed-meshheading:6734697-Kinetics,
pubmed-meshheading:6734697-Liver Cirrhosis,
pubmed-meshheading:6734697-Liver Function Tests,
pubmed-meshheading:6734697-Male,
pubmed-meshheading:6734697-Middle Aged
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pubmed:year |
1984
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pubmed:articleTitle |
Pharmacokinetics of cimetidine in advanced cirrhosis.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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