Linked Life Data

673441

Source:http://linkedlifedata.com/resource/pubmed/id/673441

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-9-15
pubmed:abstractText
The effects of aspirin and morphine on the release of bradykinin-like substance into the substaneous perfusate following various noxious stimuli were investigated in rat paw preparation. Subcutaneous perfusion was performed with saline or with saline containing o-phenanthroline or soy bean trypsin inhibitor at a rate of 3--4 drops/min. Ten drops per fraction were assayed for bradykinin activity. Pressure on the instep, application of heat to the foot and stimulation of the sciatic nerve were employed as noxious stimuli. Aspirin (200 mg/kg i.p.) inhibited the release of bradykinin due to heat, pressure and sciatic nerve stimulation, while morphine (5 mg/kg i.m.) inhibited only the release of bradykinin due to sciatic nerve stimulation. Results suggest that analgesics, such as aspirin and morphine, have a depressant action on pain by inhibiting the release of bradykinin locally. They also suggest that aspirin inhibits the release of bradykinin regardless of the type of noxious stimuli, while morphine inhibits the release of bradykinin which is mediated by neural mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0304-3959
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-63
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Effects of aspirin and morphine on the release of a bradykinin-like substance into the subcutaneous perfusate of the rat paw.
pubmed:publicationType
Journal Article