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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1984-7-30
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pubmed:abstractText |
Evidence is presented for an inhibitory action of the bone marrow adherent cell layer on erythropoiesis in a case of pure red cell aplasia. Cultures of the patient's bone marrow with autologous and normal plasma showed normal numbers of CFU-C, but total absence of BFU-E. There was no inhibition of BFU-E when normal bone marrow was cultured with the patient's plasma. T-cell depletion of the patient's bone marrow did not affect these results, but after removal of the adherent cells, normal numbers of BFU-E were cultured. These observations suggest that the adherent cells, which are predominantly macrophages, were responsible for the inhibitory action on erythropoiesis.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0141-9854
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
6
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
61-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6734100-Aged,
pubmed-meshheading:6734100-Anemia, Aplastic,
pubmed-meshheading:6734100-Bone Marrow,
pubmed-meshheading:6734100-Colony-Forming Units Assay,
pubmed-meshheading:6734100-Erythropoiesis,
pubmed-meshheading:6734100-Humans,
pubmed-meshheading:6734100-Immune Adherence Reaction,
pubmed-meshheading:6734100-Macrophages,
pubmed-meshheading:6734100-Male
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pubmed:year |
1984
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pubmed:articleTitle |
Pure red cell aplasia--evidence for an inhibitory action of the bone marrow adherent cell layer.
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pubmed:publicationType |
Journal Article,
Case Reports
|