Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8016
pubmed:dateCreated
1977-6-11
pubmed:abstractText
During 1975 twenty-six bereaved spouses took part in a detailed prospective investigation of the effects of severe stress on the immune system. T and B cell numbers and function, and hormone concentrations were studied approximately 2 weeks after bereavement and 6 weeks thereafter. The response to phytohaemagglutinin was significantly depressed in the bereaved group on the second occasion, as was the response to concanavalin A at 6 weeks. There was no difference in T and B cell numbers, protein concentrations, the presence of autoantibodies and delayed hypersensitivity, and in cortisol, prolactin, growth hormone, and thyroid hormone assays between the bereaved group and the controls. This is the first time severe psychological stress has been shown to produce a measurable abnormality in immune function which is not obviously caused by hormonal changes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
834-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:67339-Adult, pubmed-meshheading:67339-Aged, pubmed-meshheading:67339-Autoantibodies, pubmed-meshheading:67339-B-Lymphocytes, pubmed-meshheading:67339-Blood Proteins, pubmed-meshheading:67339-Concanavalin A, pubmed-meshheading:67339-Grief, pubmed-meshheading:67339-Growth Hormone, pubmed-meshheading:67339-Humans, pubmed-meshheading:67339-Hydrocortisone, pubmed-meshheading:67339-Hypersensitivity, Delayed, pubmed-meshheading:67339-Immunoglobulins, pubmed-meshheading:67339-Immunologic Techniques, pubmed-meshheading:67339-Lectins, pubmed-meshheading:67339-Lymphocyte Activation, pubmed-meshheading:67339-Middle Aged, pubmed-meshheading:67339-Prolactin, pubmed-meshheading:67339-Prospective Studies, pubmed-meshheading:67339-Stress, Psychological, pubmed-meshheading:67339-T-Lymphocytes, pubmed-meshheading:67339-Thyroid Hormones
pubmed:year
1977
pubmed:articleTitle
Depressed lymphocyte function after bereavement.
pubmed:publicationType
Journal Article