Linked Life Data

6733971

Source:http://linkedlifedata.com/resource/pubmed/id/6733971

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-8-7
pubmed:abstractText
BXSB male mice, which spontaneously develop a systemic lupus erythematosus (SLE) like disease, were the only strain to have a significant incidence of abnormally elevated levels of gp70 in sera. Concentrations of gp70 in some mice were more than 10 times (greater than 500 micrograms/ml) those of young BXSB and any other murine strain. The presence of high serum levels of gp70 was significantly associated with hepatic sinusoidal lymphocytosis, a high incidence of which was only observed in male BXSB mice. Serum levels of gp70-anti-gp70 immune complexes were greatly increased in mice with high levels of gp70, presumably associated with increased anti-gp70 antibody production. Such mice developed fatal glomerulonephritis significantly earlier than those with lower levels of gp70. These results suggest that (1) hepatic inflammation of unknown aetiology occurring uniquely in male BXSB mice during the course of their SLE may be responsible for the enhanced expression of serum gp70 antigen, because of its nature as an acute phase reactant and (2) enhanced expression of gp70 antigen is associated with increased formation of anti-gp70 antibodies and exacerbation of lupus nephritis in male BXSB mice.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-14218486, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-163885, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-172586, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-182895, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-185799, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-193039, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-212505, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-221610, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-309911, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-46910, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-5576334, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-6601614, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-6969775, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-7027259, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-7057139, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-7252417, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-7264564, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-7288364, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-7371228, http://linkedlifedata.com/resource/pubmed/commentcorrection/6733971-795575
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
272-80
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Association of elevated serum glycoprotein gp70 with increased gp70 immune complex formation and accelerated lupus nephritis in autoimmune male BXSB mice.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't