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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1984-7-30
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pubmed:abstractText |
Two sisters in whom a diagnosis of Fanconi's anemia was made at ages 12 and 18 subsequently developed acute nonlymphocytic leukemia (ANLL). A third sibling had previously died at age 11 of apparent sepsis. Both sisters had cytogenetic studies that showed increased chromosomal breakage and a 46,XX karyotype, but subsequently developed ANLL after, or coincident with, the emergence of monosomy 7. These observations suggest that, in addition to myelodysplastic syndromes and defective neutrophil chemotaxis, monosomy 7 may be associated with the emergence of leukemia in this disorder.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-4971
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6733270-Acute Disease,
pubmed-meshheading:6733270-Adolescent,
pubmed-meshheading:6733270-Anemia, Aplastic,
pubmed-meshheading:6733270-Child,
pubmed-meshheading:6733270-Chromosome Aberrations,
pubmed-meshheading:6733270-Chromosome Deletion,
pubmed-meshheading:6733270-Chromosomes, Human, 6-12 and X,
pubmed-meshheading:6733270-Fanconi Anemia,
pubmed-meshheading:6733270-Female,
pubmed-meshheading:6733270-Humans,
pubmed-meshheading:6733270-Karyotyping,
pubmed-meshheading:6733270-Leukemia
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pubmed:year |
1984
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pubmed:articleTitle |
Transformation of Fanconi's anemia to acute nonlymphocytic leukemia associated with emergence of monosomy 7.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports,
Research Support, Non-U.S. Gov't
|