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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1984-8-7
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pubmed:abstractText |
An expression is derived for the lipid-mediated intermolecular interaction between protein molecules embedded in a lipid bilayer. It is assumed that protein particles are accommodated by the bilayer, but they distort the lipids in some manner from their equilibrium protein-free configuration. We treat this situation by expanding the free energy density in the plane of the membrane as a Taylor series in some arbitrary parameter and its gradient. Minimization of the total membrane energy for a given particle configuration yields the interparticle interaction energy for that configuration. A test of the model is provided by measurement of the protein-protein pair distribution function from freeze-fracture micrographs of partially aggregated membranes. The measured functions can be simulated by adjustment of two parameters (a) a lipid correlation length that characterizes the distance over which a distortion of the bilayers is transmitted laterally through the bilayer, and (b) a term quantifying the energy of the protein-lipid interaction at the protein-lipid boundary. Correlation lengths obtained by fitting the calculated particle distribution functions to the data are found to be several nanometers. Protein-lipid interaction energies are of the order of a few kT.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-1260065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-1276388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-153147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-174727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-204347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-225184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-228706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-273895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-291895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-326156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-383152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-4135001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-4356540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-4357019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-4399200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-4424225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-4600883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-4629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-4782838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-497182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-5062322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-6180764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-6243483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-62894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-647003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-660655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-6616005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-6773540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-6854643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-6892884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-69714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-7272460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-7353006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-7569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-7677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-769162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-793632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-798475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-971438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6733239-990322
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-3495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
863-71
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1984
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pubmed:articleTitle |
Statistical mechanics of lipid membranes. Protein correlation functions and lipid ordering.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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