Linked Life Data

6729246

Source:http://linkedlifedata.com/resource/pubmed/id/6729246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-6-27
pubmed:abstractText
The effect of pretreatment of rats with three daily i.p. doses of 25, 50 and 100 mg/kg of the antiarrhythmic agent, amiodarone, on the activity of some hepatic drug metabolizing enzymes, on the levels of cytochromes P-450 and b5 as well as on lipid peroxidation is reported. Amiodarone at doses of 50 and 100 mg/kg significantly reduced the hydroxylation of aniline, the 0- and N-demethylations of p-nitroanisole and aminopyrine respectively and the level of cytochromes P-450. No inhibition in enzymic activity was observed with the 25 mg/kg dose. Testosterone hydroxylation was only depressed with the 100 mg/kg dose; in this case, all four hydroxylation reactions were reduced. Cytochrome b5 content and lipid peroxidation were significantly decreased with doses of 25 and 50 mg/kg. Addition of 1 mM of amiodarone to incubation mixtures containing either aminopyrine or p-nitroanisole or aniline only decreased aniline hydroxylation indicating that at high doses amiodarone acts as a competitive inhibitor of aniline hydroxylase but that the depressive effect observed on the 0- and N-demethylations of p-nitroanisole and aminopyrine is mediated via an indirect mechanism. The inhibitory effect of amiodarone was also shown in vivo by an increase in the elimination half-life and a decrease in the clearance of antipyrine. The results reported herein may explain, in part at least, the drug interactions recently reported in man with amiodarone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Depressive effect of amiodarone on hepatic drug metabolism in the rat.
pubmed:publicationType
Journal Article, In Vitro