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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1984-6-22
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pubmed:abstractText |
New derivatives of isoindole -4,7-dione have been synthesized and their radiation sensitization and chemical behavior have been studied. One-electron reduction potentials have been determined by pulse radiolysis and found to be in the range of -0.45 to -0.36 V vs NHE . Radiosensitization effects were tested in vivo using soft tissue sarcoma transplanted in mice. All the isoindole -4,7-diones tested were found to exert considerable radiosensitization, approaching that of misonidazole tested under comparable conditions. The derivatives which contain a carbethoxy group on the pyrrolic ring were found to have more positive reduction potentials and to act as more efficient sensitizers. Further development of this class of radiosensitizers is underway.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0033-7587
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
234-41
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6729035-Animals,
pubmed-meshheading:6729035-Chemical Phenomena,
pubmed-meshheading:6729035-Chemistry,
pubmed-meshheading:6729035-Indoles,
pubmed-meshheading:6729035-Mice,
pubmed-meshheading:6729035-Mice, Inbred BALB C,
pubmed-meshheading:6729035-Misonidazole,
pubmed-meshheading:6729035-Neoplasm Transplantation,
pubmed-meshheading:6729035-Pulse Radiolysis,
pubmed-meshheading:6729035-Radiation-Sensitizing Agents,
pubmed-meshheading:6729035-Sarcoma, Experimental
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pubmed:year |
1984
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pubmed:articleTitle |
Radiosensitization by derivatives of isoindole-4,7-dione.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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