Linked Life Data

6723805

Source:http://linkedlifedata.com/resource/pubmed/id/6723805

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-7-11
pubmed:abstractText
We have examined the morphological development of optic nerve aplasia in a subpopulation (10-20%) of anophthalmic mice (Strain ZRDCT -AN) that develop microphthalmia. During embryonic stages the optic fissure in microphthalmic mutants did not involute into the optic stalk. Even in the absence of a proper fissure, early differentiation of the various retinal elements was not disturbed. Subsequently, however, the optic nerve fibers failed to exit from the eye in their appropriate position. Secondary changes in the retina, probably resulting from a failure of optic axons to reach their central targets, were near total loss of ganglion cells and variable attenuation of the other nuclear and plexiform layers. Retinal rosettes were also commonly present.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
257-66
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Development and aging of the eye in mice with inherited optic nerve aplasia: histopathological studies.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.