Linked Life Data

6723484

Source:http://linkedlifedata.com/resource/pubmed/id/6723484

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1984-7-6
pubmed:abstractText
Continuous mechanical and electrical activity recordings of the gastroduodenal junction and duodenum were performed in conscious sheep receiving pharmacologic agents delivered intraduodenally before and after nerve section. Sheep on a normal diet regimen exhibited cyclic periods of maximal activity (phase III of the migrating myoelectric complex) on the duodenum or in-series contractions on the duodenal bulb recurring at a frequency of 13/24 hr and more after nerve section. Among the variety of agents triggering in intact animals premature phases of maximal activity, methysergide, when administered locally, was found to increase the number of complexes to a frequency of 24/24 hr, even when extrinsic nerve supply was removed. The results suggest that in the ovine model the mechanism of cycling of the motor events involved serotonergic myenteric neurons located in the duodenal bulb. The data were consistent with the regulation of the enteric biological clock via 5HT neural receptors mediating inhibition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0163-2116
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
520-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Involvement of serotonergic mechanisms in initiation of small intestine cyclic motor events.
pubmed:publicationType
Journal Article