Linked Life Data

6717567

Source:http://linkedlifedata.com/resource/pubmed/id/6717567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5961
pubmed:dateCreated
1984-5-30
pubmed:abstractText
The mossy-fibre axons of the hippocampus form a dense plexus, uniquely rich in chelatable zinc. Because the metal is apparently concentrated within the terminal bags of the axons, it has been hypothesized that the zinc is involved in mossy-fibre synaptic transmission. Although some electrophysiological findings have favoured the hypothesis, neither preferential uptake of zinc into the hippocampus nor depolarization-induced release of zinc from hippocampal tissue has previously been found. Using the hippocampal slice preparation, we now report that the mossy-fibre neuropil and cells of origin (dentate granule cells) take up zinc preferentially, and that electrical stimulation selectively facilitates both uptake of exogenous zinc into mossy-fibre neuropil and release of previously incorporated 65Zn from the tissue. The results suggest that the role of zinc in mossy-fibre axons is dynamically linked to neural signalling processes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:volume
308
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
736-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Stimulation-induced uptake and release of zinc in hippocampal slices.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.