Linked Life Data

6716132

Source:http://linkedlifedata.com/resource/pubmed/id/6716132

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-6-1
pubmed:abstractText
The effects of acute administration of amphetamine on membrane potentials and evoked postsynaptic potentials of caudate neurons in cats were assessed using intracellular recording. High doses of amphetamine (0.5 mg/kg, i.v.) produced a reversible depolarization of the cell membrane in 78% of cells tested. Low doses (0.1 mg/kg) had no effect on the resting membrane potential. Long-lasting increases in amplitude of both excitatory and inhibitory components of evoked postsynaptic potential sequences were observed after both high and low doses of amphetamine. These changes were more evident to cortical than to substantia nigra or to intralaminar thalamic stimulation. These results were shown to be independent of the peripheral autonomic actions of amphetamine. These effects appear to be mediated by the ability of amphetamine to alter catecholaminergic mechanisms in the caudate nucleus and suggest that increased dopamine release may have a facilitatory effect on both excitatory and inhibitory synaptic transmission.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
930-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Effects of amphetamine on intracellular responses of caudate neurons in the cat.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.