Linked Life Data

6715413

Source:http://linkedlifedata.com/resource/pubmed/id/6715413

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-6-5
pubmed:abstractText
Family trees of rat liver epitheliallike cells (RLECs), which proliferate finitely in primary culture, were obtained by time-lapse cinemicrography (TLC). In family trees, RLECs were classified into those terminated with division (class D cells), those terminated with incomplete division (class l cells), i.e., division followed by fusion of two daughter cells, and the combined population (class N cells) of those terminated with death and those surviving for 120 hr or more with their termination not detected by TLC. The interphase period, but not the intersibling period, of class D cells became distributed more broadly with time on the family tree. These results for class D cells fit best to a transition probability model with two indeterminate states (Brooks et al., Cell, 19:493-504, 1980) when the model is modified in such a way that the transition probability for one of the two indeterminate states decreases with time. During proliferation of RLECs, some of the class D cells reproduce, while others showed transition, in part by way of class l cells, to class N cells. The frequency of transition from class D to class N increased with time in the family tree. Two sibling cells of a parent mitotic cell were simultaneously either class D or class N at a significantly high frequency, suggesting that the transition had been determined in the preceding cells. The present observations confirm previously described observations on human diploid cells, and in addition, reveal some new details of the finitely proliferative nature of somatic diploid cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9541
pubmed:author
pubmed:issnType
Print
pubmed:volume
119
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-54
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Sequence of cell life phases in a finitely proliferative population of cultured rat cells: a genealogical study.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't