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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1984-6-19
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pubmed:abstractText |
Decreased erythrocyte glutathione s-transferase activity was found in workers exposed to hot rubber fumes in two-roll mill and calender departments (6.6 +/- 0.9 and 6.8 +/- 0.8 mumol/min X mg haemoglobin, respectively vs 8.4 +/- 0.5 in controls). This trend was also noted in the general category of all rubber exposed workers without stratification according to their task (7.6 +/- 0.5, n = 30). This result was contrary to that expected, as the cases with the lowest values had the greatest urinary thioether excretion. The thioethers are the end-products of the enzyme-catalyzed glutathione conjugation reaction aimed at the inactivation of potentially toxic chemicals. Thus, it appears that the assay of erythrocyte glutathione s-transferase activity is not very informative about exposure, although the enzyme assay might disclose other, so far unknown, biological effects of reactive rubber chemicals.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0340-0131
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-302
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6715053-Depression, Chemical,
pubmed-meshheading:6715053-Erythrocytes,
pubmed-meshheading:6715053-Female,
pubmed-meshheading:6715053-Glutathione Transferase,
pubmed-meshheading:6715053-Humans,
pubmed-meshheading:6715053-Male,
pubmed-meshheading:6715053-Occupational Diseases,
pubmed-meshheading:6715053-Rubber
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pubmed:year |
1984
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pubmed:articleTitle |
Decreased erythrocyte glutathione s-transferase activity in rubber workers.
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pubmed:publicationType |
Journal Article
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