Linked Life Data

6714350

Source:http://linkedlifedata.com/resource/pubmed/id/6714350

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-6-7
pubmed:abstractText
Sympathetic axons have been shown to invade the rat hippocampal formation after lesions of the septohippocampal (cholinergic) projection. To test the generality of this type of transmitter-specific sprouting within the central nervous system, lesions were placed within the horizontal limb of the diagonal band in order to denervate the main olfactory bulb (MOB) of its cholinergic innervation. Some animals also received autologous transplants of the superior cervical ganglion to the region of the MOB. There was no evidence of sympathetic axon growth into the MOB under any circumstance as assessed with qualitative fluorescence histochemistry. In addition, retrograde fluorescent dye studies demonstrated that the basal forebrain neurons projecting to the neocortex, where sympathetic sprouting has also been reported, are a separate population from those which project to the MOB. Although it is difficult to unequivocally interpret negative results, these data indicate that cholinergic denervation does not induce sympathetic sprouting throughout the central nervous system. The availability of a brain region where sympathetic sprouting does not occur may provide clues to understanding the conditions which permit such neuronal plasticity in the hippocampal formation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
386-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Absence of sympathetic sprouting in the rat olfactory bulb after cholinergic denervation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.