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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0001480,
umls-concept:C0006104,
umls-concept:C0011570,
umls-concept:C0017725,
umls-concept:C0205147,
umls-concept:C0205155,
umls-concept:C0205171,
umls-concept:C0232338,
umls-concept:C0332261,
umls-concept:C0392747,
umls-concept:C0439799,
umls-concept:C0456205,
umls-concept:C1176472,
umls-concept:C1522472,
umls-concept:C1550605,
umls-concept:C1551341,
umls-concept:C1552858,
umls-concept:C1552923,
umls-concept:C1552924,
umls-concept:C1705191,
umls-concept:C1709474,
umls-concept:C1882598
|
| pubmed:issue |
2
|
| pubmed:dateCreated |
1984-6-7
|
| pubmed:abstractText |
Hemodynamic and biochemical substrate changes are associated with cortical spreading depression (CSD). Regional methods were used to measure blood flow, and glucose and ATP concentrations in intact brain sections in rats undergoing a single passage of cortical spreading depression. Changes were expressed as the percentages of the contralateral homotopic area of the unaffected cortex. A depression in tissue ATP content preceded the negative DC potential shift and ATP was reduced by 12% (P less than 0.01) despite unaltered blood flow and glucose concentration. When the negative shift of DC potential reached its maximum, glucose content decreased to 72% of control (P less than 0.01) and was accompanied by a further ATP decrease to 54%. When the cortical steady potential declined, blood flow was elevated twofold (P less than 0.01). The ATP content gradually returned to normal; however, cortical glucose concentrations remained at 55% of control values. The relationship of blood flow and glucose and ATP concentration with other known changes during spreading depression are discussed. With the advantage of higher resolution the provided techniques may be a useful tool for studies on hemodynamic and biochemical changes of other pathophysiologic conditions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0014-4886
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
84
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
249-58
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:6714339-Adenosine Triphosphate,
pubmed-meshheading:6714339-Animals,
pubmed-meshheading:6714339-Cerebral Cortex,
pubmed-meshheading:6714339-Cortical Spreading Depression,
pubmed-meshheading:6714339-Glucose,
pubmed-meshheading:6714339-Rats,
pubmed-meshheading:6714339-Rats, Inbred Strains,
pubmed-meshheading:6714339-Regional Blood Flow
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Regional changes of blood flow, glucose, and ATP content determined on brain sections during a single passage of spreading depression in rat brain cortex.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|