Linked Life Data

6714304

Source:http://linkedlifedata.com/resource/pubmed/id/6714304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-6-6
pubmed:abstractText
Some functions of pre- and postsynaptic alpha-receptors were compared in isolated dog arteries. In mesenteric and renal arteries, contractile responses to transmural electrical stimulation were potentiated by yohimbine, a selective alpha 2-antagonist; the potentiation was greater in mesenteric arteries. Concentration-response curves for norepinephrine were shifted to the right by high concentrations of yohimbine. Prazosin, a selective alpha 1-antagonist, in low concentrations preferentially attenuated the contractile response to transmural stimulation, when compared with the response to equiactive concentrations of norepinephrine. Relaxant responses of coronary arteries to transmural stimulation were also potentiated by yohimbine. Relaxations induced by norepinephrine were not influenced by yohimbine but were potentiated by prazosin. Contractile responses of coronary arteries treated with propranolol to transmural stimulation were abolished by prazosin. It is concluded that the involvement of presynaptic alpha 2-receptors in the negative feedback mechanism in transmitter release differs in a variety of dog arteries and that the adrenoceptors subserving contraction are of both subtypes (alpha 1 and alpha 2) in the mesenteric and renal arteries, but only of the alpha 1 subtype in coronary artery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-78
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Modification by yohimbine and prazosin of the mechanical response of isolated dog mesenteric, renal and coronary arteries to transmural stimulation and norepinephrine.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't