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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1984-6-21
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pubmed:abstractText |
3-methylindole was administered orally and intravenously to horses and ponies in order to determine the ability of this chemical to provide a model of equine pulmonary disease. Both routes produced a severe and sometimes fatal pulmonary disease, characterised by bronchiolitis. Clinical signs developed 48 to 72 h after dosing and were most severe between Days 4 and 10 post dosing. Intravenous administration of 3-methylindole produced lung injury more rapidly and at a lower dose rate than the oral route. It is suggested that the respiratory condition induced by this chemical could become a method for standardisation of lung function techniques and interpretation in equine obstructive pulmonary disease.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0425-1644
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
16
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
108-12
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6714211-Animals,
pubmed-meshheading:6714211-Bronchi,
pubmed-meshheading:6714211-Disease Models, Animal,
pubmed-meshheading:6714211-Horse Diseases,
pubmed-meshheading:6714211-Horses,
pubmed-meshheading:6714211-Indoles,
pubmed-meshheading:6714211-Lung Diseases, Obstructive,
pubmed-meshheading:6714211-Male,
pubmed-meshheading:6714211-Respiration,
pubmed-meshheading:6714211-Skatole
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pubmed:year |
1984
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pubmed:articleTitle |
3-methylindole as a model of equine obstructive lung disease.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|