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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1978-9-29
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Adolescent Pregnancy,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Procedures,
http://linkedlifedata.com/resource/pubmed/keyword/PREGNANCY TESTS,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy Tests, Immunologic,
http://linkedlifedata.com/resource/pubmed/keyword/Progestational Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Progesterone--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Prospective Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Studies
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0024-7758
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
260-4
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:otherAbstract |
PIP: The efficacy of administering progesterone alone for the early diagnosis of pregnancy was evaluated in a study of 296 women presenting to an outpatient clinic because of a recently missed menstrual period and requesting termination of the suspected pregnancy. Subjects met 4 criteria: 1) no preexisting medical or gynecological condition; 2) regular menstrual cycles with a range of 21-35 days; 3) no more than 14 days past the expected date of menstrual onset; and 4) no immediate request for oral contraceptives or the IUD. 148 patients in the treatment group received an intramuscular injection of 100 mg progesterone, while the 143 controls were given no hormonal injection. At the 1st follow-up visit 10 days later, the pregnancy test (Pregnosticon Dri-Dot) was repeated, and vacuum aspiration performed if the patient was still amenorrhetic, with the contents submitted for pathological study. The 2nd follow-up was 2-4 weeks later. 33.8% of women in the treatment group and 34.9% of controls menstruated within 10 days of the initial visit. Those in the treatment group were significantly more likely (57.4%) than controls (35.7%) to report at least 1 complaint. There were no significant differences between groups in the number of women who were pregnant or underwent menstrual regulation, implying that progesterone does not act as an abortifacient. Since the failure of progesterone to induce withdrawal bleeding is presumed to indicate pregnancy, its false-positive rate as a hormonal test of pregnancy was 15.3% in the treatment group, compared with 24.3% for the urine pregnancy test at the initial visit but 6.9% for the Pregnosticon test at 10 days. A false-negative rate of 4.1% was associated with the hormonal pregnancy test, compared with 29.3 and 18.8%, for the Pregnosticon test at the initial and 10-day follow-up visits, respectively. The study design contained 2 limitations: 1) histologic specimens of uterine contents were obtained only from those who seemed pregnant; and 2) no placebo injection was given to controls. It is concluded that progesterone administration offers no clear-cut advantage to immunologic pregnancy tests, and carries possible disadvantages in terms of increased risks of birth defects.
|
| pubmed:meshHeading | |
| pubmed:year |
1978
|
| pubmed:articleTitle |
An evaluation of intramuscular progesterone for the diagnosis of early pregnancy.
|
| pubmed:publicationType |
Journal Article
|