Linked Life Data

6713212

Source:http://linkedlifedata.com/resource/pubmed/id/6713212

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-6-1
pubmed:abstractText
Intraperitoneal administration of phenelzine (PLZ) or of beta-phenylethylamine (PE) quickly leads to short periods of behavioural activation, which are primarily dopaminergic and serotonergic in nature, respectively. In order to determine whether these behavioural effects are due to PLZ- or PE-induced displacement of dopamine (DA) or serotonin (5HT), the ability of these compounds to stimulate release of radiolabelled DA and 5HT from slices of rat striatum was assessed. Additionally, at various times following IP administration of behaviourally active doses of PLZ or PE to rats, the striatal levels of the drugs were measured. Both PLZ and PE were able to stimulate a greater release of radiolabelled DA than of 5HT. Lower concentrations of PE (0.8, 8.0 microM) than of PLZ (100 microM, 1 mM) stimulated release. The striatal levels (approximately 200 microM) of PLZ, as well as of PE, attained at times corresponding to behavioural activation seemed sufficient to cause release of both DA and 5HT. It was concluded, therefore, that the mode of action of these compounds may involve displacement, or release, of these biogenic amines, though it is not clear how such release ultimately leads to the behaviours observed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The behavioural effects of phenelzine and phenylethylamine may be due to amine release.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't