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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1984-5-11
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pubmed:abstractText |
Megakaryocytes isolated in high purity from guinea pigs produced thromboxane B2 in response to exogenously provided arachidonic acid. This production was inhibited by in vitro treatment with acetylsalicylic acid with a concentration response relationship similar to that seen in platelets. During in vitro culture, the aspirin-treated megakaryocytes recovered thromboxane synthetic ability. Following a lag of 12 hours, recovery of megakaryocyte thromboxane production resumed at a rate of 16% of control per day. This recovery was inhibited by the addition of cycloheximide to the culture medium.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
30
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
982-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6712680-Animals,
pubmed-meshheading:6712680-Aspirin,
pubmed-meshheading:6712680-Blood Platelets,
pubmed-meshheading:6712680-Cells, Cultured,
pubmed-meshheading:6712680-Guinea Pigs,
pubmed-meshheading:6712680-Kinetics,
pubmed-meshheading:6712680-Megakaryocytes,
pubmed-meshheading:6712680-Radioimmunoassay,
pubmed-meshheading:6712680-Thromboxane B2,
pubmed-meshheading:6712680-Thromboxanes
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pubmed:year |
1984
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pubmed:articleTitle |
Recovery of megakaryocyte thromboxane production in vitro after aspirin inhibition.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|