Linked Life Data

6711478

Source:http://linkedlifedata.com/resource/pubmed/id/6711478

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1984-5-24
pubmed:abstractText
To evaluate the need for intraluminal pancreaticobiliary secretions for mucosal adaptation in animals with short bowel, groups of paired rats were prepared with: 1) normal bowel length, 2) 60% proximal small bowel bypass, and 3) similar bypass of distal bowel. One animal in each pair underwent operative diversion of pancreaticobiliary secretions to distal (group 1) or bypassed intestine (groups 2 and 3). Rats were fed an elemental diet and killed 1 month later. Mucosal wet weight, protein content, and DNA content were measured in comparable segments of proximal jejunum and mid-small bowel. Within each group the patterns of response of the three measures of mucosal mass were similar. Group 1: removal of secretions was associated with a 20 to 30% increase in mass in both segments. Group 2: after proximal bypass, mass doubled in mid-small bowel (in continuity) whether or not pancreaticobiliary secretions were removed. Group 3: after distal bypass, no change in mass was apparent in the jejunum even with removal of secretions. We conclude that intraluminal pancreaticobiliary secretions are not required for maintenance of mucosal mass or adaptation to short bowel in animals fed an elemental diet.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-9165
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
762-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Effect of removal of pancreaticobiliary secretions on adaptation to short bowel in orally nourished rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't