Linked Life Data

671091

Source:http://linkedlifedata.com/resource/pubmed/id/671091

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1978-9-25
pubmed:abstractText
The effects of parenteral administration of aminoethyl phosphonic acid (AEP) on the liver microsomal drug metabolism and ultrastructure were studied in normal and 1% cholesterol-fed albino rats. AEP administration to rats fed a stock-diet resulted in decreased demethylation of aminopyrine with a concomitant fall in cytochrome P-450 level. Aniline hydroxylation remained unaltered. AEP injection to cholesterol-fed rats, caused marked reduction in both aminopyrine demethylation and aniline hydroxylation, with a significant increase in cytochrome P-450 level. AEP injection to both control and cholesterol-fed animals produced a modest increase in Bilirubin UDP-glucuronyl transferase. RNA:DNA ratio showed remarkable elevation in rats fed the cholesterol diet with AEP injection. AEP injection caused an atypical smooth endoplasmic reticulum and a marked loss of nuclear euchromatin. Effect of AEP was more pronounced in rats receiving the cholesterol-diet. AEP administration thus induces structural and drug metabolic enzyme alteration in liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1234-43
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
The effects of aminoethyl phosphonic acid on hepatic microsomal drug metabolism and ultrastructure of normal and cholesterol fed rats.
pubmed:publicationType
Journal Article