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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1984-5-11
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pubmed:abstractText |
Macromolecular binding of metals is thought to be a prerequisite for induction of metal sensitivity. In this study, the binding of cobalt(II) to blood components was investigated. Incubation of 60Co with blood yielded a mean erythrocyte binding of 10.3 X 10(7) Co atoms/cell. Incubation of the metal with serum resulted in binding of 8.3 X 10(-9) mol Co/mg protein. A comparison was made with analogous binding of chromium(III), a metal recognized for its sensitizing potency. Binding of chromium to proteins and blood cells was 20-fold higher than that obtained with cobalt. With both metals, binding to serum proteins was non-specific. The greater binding by chromium, when compared with cobalt, is consistent with the greater sensitizing ability of this metal.
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pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0300-483X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125-33
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading | |
pubmed:year |
1984
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pubmed:articleTitle |
Comparison of cobalt and chromium binding to blood elements.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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