Linked Life Data

6710516

Source:http://linkedlifedata.com/resource/pubmed/id/6710516

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-5-2
pubmed:abstractText
The effect of administration of lead in the maternal drinking water from conception to weaning on enkephalin levels in the developing rat striatum was studied between 10 and 100 days after birth. Concentrations of 300 and 1000 ppm Pb produced no overt toxicity in terms of effects on body and brain weight. However, marked differences in striatal enkephalins were observed. In lead-dosed animals enkephalin content was up to 50% lower at 10 and 21 days postpartum, and in addition lead appeared to delay the attainment of adult levels of this opioid neurotransmitter. Measures at later time points indicated that the effects of lead on enkephalin are reversible. The results suggest that lead depresses and delays the ontogeny of the enkephalinergic system within the striatum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0041-008X
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
30-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The effect of perinatal lead administration on the ontogeny of striatal enkephalin levels in the rat.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't