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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1984-5-4
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pubmed:abstractText |
Anovlar induces a mitodepressive effect, producing abnormal prophases and a considerable number of micronuclei, i.e. Anovlar can produce major cytological abnormalities. On the other hand, Lyndiol induces minor abnormalities leaving the process of mitosis to proceed almost normally. Microgynon 30 did not show any effect on any of the mitotic stages. Our conclusion may offer an explanation for the contradictory results found in the literature upon the cytological effect of oral contraceptives, although the major chemical constitution of all contraceptives used is the same, still there are minor differences in their chemical structure. These minor differences in chemical structure may be the deciding cause whether or not a contraceptive is harmful.
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/ANATOMY,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/CHROMOSOME ABNORMALITIES,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Female--side...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Ethinyl Estradiol--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Histology,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Procedures,
http://linkedlifedata.com/resource/pubmed/keyword/Lynestrenol--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Mestranol--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Neonatal Diseases And Abnormalities,
http://linkedlifedata.com/resource/pubmed/keyword/Norethindrone Acetate--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Norethindrone--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Norgestrel,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Reproductive Control Agents
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral,
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral, Combined,
http://linkedlifedata.com/resource/pubmed/chemical/Ethinyl Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Ethinyl Estradiol-Norgestrel...,
http://linkedlifedata.com/resource/pubmed/chemical/Lynestrenol,
http://linkedlifedata.com/resource/pubmed/chemical/Mestranol,
http://linkedlifedata.com/resource/pubmed/chemical/Mutagens,
http://linkedlifedata.com/resource/pubmed/chemical/Noracycline,
http://linkedlifedata.com/resource/pubmed/chemical/Norethindrone,
http://linkedlifedata.com/resource/pubmed/chemical/Norgestrel,
http://linkedlifedata.com/resource/pubmed/chemical/ethynylestradiol mixture with...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-5107
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-8
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pubmed:dateRevised |
2008-11-21
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pubmed:otherAbstract |
PIP: Anovlar induces a mitodepressive effect, producing abnormal prophases and a considerable number of micronuclei, i.e., Anovlar can produce major cytological abnormalities. Conversely, Lyndiol induces minor abnormalities leaving the process of mitosis to proceed almost normally. Microgynon 30 did not show any effect on any of the mitotic stages. The conclusion may offer an explanation for the contradictory results found in the literature of the cytological effect of oral contraceptives, although the major chemical constitution of all contraceptives used is the same, still there are minor differences in their chemical structure. These minor differences may be the deciding factor as to whether or not a contraceptive is harmful.
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pubmed:meshHeading |
pubmed-meshheading:6708960-Cell Cycle,
pubmed-meshheading:6708960-Cell Nucleus,
pubmed-meshheading:6708960-Contraceptives, Oral,
pubmed-meshheading:6708960-Contraceptives, Oral, Combined,
pubmed-meshheading:6708960-Ethinyl Estradiol,
pubmed-meshheading:6708960-Ethinyl Estradiol-Norgestrel Combination,
pubmed-meshheading:6708960-Lynestrenol,
pubmed-meshheading:6708960-Mestranol,
pubmed-meshheading:6708960-Mitosis,
pubmed-meshheading:6708960-Mutagenicity Tests,
pubmed-meshheading:6708960-Mutagens,
pubmed-meshheading:6708960-Mutation,
pubmed-meshheading:6708960-Norethindrone,
pubmed-meshheading:6708960-Norgestrel,
pubmed-meshheading:6708960-Plant Physiological Phenomena,
pubmed-meshheading:6708960-Plants,
pubmed-meshheading:6708960-Structure-Activity Relationship
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pubmed:year |
1984
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pubmed:articleTitle |
Further investigations on the cytological effects of some contraceptives.
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pubmed:publicationType |
Journal Article,
Comparative Study
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