Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1984-5-11
pubmed:abstractText
Chick lumbosacral motoneurones were caused to innervate foreign muscles by surgically rotating or shifting the limb bud about the anterior-posterior axis in stage 17-18 embryos. The activation pattern of such wrongly projecting motoneurones was assessed at stages 35-38 by recording electromyographic activity from muscles in an isolated spinal cord/hind limb preparation. Muscle activity was classed as flexor- or extensor-like according to the characteristics of the patterned sequence of bursts elicited by a single shock to the thoracic cord. Wrongly projecting motoneurones did not have their activation pattern altered to one appropriate for the muscle innervated; therefore in some cases a particular muscle was activated with a pattern similar to its original one, and in other cases in an opposite manner. Mixed flexor-extensor-like activation of a single muscle was, however, rare. The identity of motoneurones projecting to a muscle was determined by their cord location following retrograde labelling with horseradish peroxidase. This allowed us to conclude that motoneurones could develop their normal pattern of activation even when projecting to foreign muscles. It is concluded that the cord circuits (presumably composed of local interneurones responsible for the activation of motoneurones in the isolated cord preparation are not altered by retrograde influences from the muscle. Wrongly projecting motoneurones, which were maintained throughout the normal cell death period, were activated during spontaneous embryonic movements, and in many cases were found to have a behaviourally inappropriate activation pattern. These observations are discussed in relation to proposed mechanisms by which developmental errors in connectivity are corrected.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-1001823, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-1123466, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-1150919, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-1268708, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-1276872, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-13725576, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-13889051, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-13952299, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-211046, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-421750, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-437035, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-448263, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-467792, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-489787, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-5147951, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-5161046, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-6121329, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-618440, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-6188639, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-6707956, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-6980277, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-7119847, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-7192292, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-7264544, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-726928, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-7298909, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-731549, http://linkedlifedata.com/resource/pubmed/commentcorrection/6707957-7414326
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-3751
pubmed:author
pubmed:issnType
Print
pubmed:volume
347
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-24
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
The activation patterns of embryonic chick motoneurones projecting to inappropriate muscles.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't