Linked Life Data

6706008

Source:http://linkedlifedata.com/resource/pubmed/id/6706008

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-5-18
pubmed:abstractText
We have derived a kinetic model to assist in the study of gene expression for systems in which rapid changes in cell number occur. This kinetic model is based upon development of the sea urchin embryo, and considers changes in the number of cells, the fraction of each cell-cycle spent in mitosis, and the overall rate of transcription. We have applied this kinetic model to the accumulation of actin messenger RNA which occurs early in sea urchin embryogenesis. This analysis demonstrates that the rapid increase in cell number profoundly influences the kinetics of mRNA accumulation, and that failure to take into account the work performed by each cell can lead to significant misinterpretations of data on the expression of specific genes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
433-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Kinetic model for the study of gene expression in the developing sea urchin.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.