Linked Life Data

6705575

Source:http://linkedlifedata.com/resource/pubmed/id/6705575

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-5-7
pubmed:abstractText
Forty percent of 89 patients with chronic airflow obstruction (CAO) demonstrated maximum expiration flow-volume (MEFV) patterns consistent with sudden collapse or marked narrowing of large central airways. In contrast, 43 percent of the CAO patients demonstrated a curvilinear (C) pattern; the remainder (17 percent) were intermediate. Volume displacement plethysmography indicated that the airway collapse (AC) pattern was influenced by, but was not solely, a gas compression artifact. Airway collapse patients had more obstruction and hyperinflation than C patients and also had decreased diffusing capacity, absence of density dependence, reduced lung recoil, and no effort dependence of airflow. Bronchodilator administration in AC patients typically produced large reduction of residual volume and increase of vital capacity, with a smaller increase of airflow. These data suggest that AC patients have significant, partially reversible peripheral airways obstruction plus emphysema. Possible determinants of AC include reduced central airway support, increased peripheral resistance, loss of lung recoil, and increased pleural pressures during forced expiration. The MEFV contour appears to evolve from normal to curvilinear to the AC pattern as the severity of airflow obstruction worsens.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0012-3692
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
476-81
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Physiologic correlates of airway collapse in chronic airflow obstruction.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.