Linked Life Data

6701451

Source:http://linkedlifedata.com/resource/pubmed/id/6701451

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-4-3
pubmed:abstractText
Thirty-three consecutive patients suffering from acute myocardial infarction were studied. Serial serum myoglobin and CK-MB measurements were made, and in seven patients individual kinetic constants for myoglobin were available from previous single injection studies. A two-compartment model for myoglobin kinetics was used for infarct size estimation. Given values for the basic kinetic constants (elimination rate constant, exchange rate constants, and distribution volume), the adjustment of a flexible, parameterized 'blood-appearance rate-function', phi AMI (mg X h-1), allowed estimation of start-time (t0), peak-time (tpeak) and end-time (tend) of myoglobin inflow into blood from the infarct area, in addition to the total cumulative release (A), which was used as a measure of infarct size. Use of patient-mean values for the kinetic constants caused a mean difference in estimated 'infarct size' of 34% (n = 7). Individual estimation of the elimination rate constant from the 'final slope' of the serum myoglobin curve could neither be recommended from a theoretical point of view nor from the practical outcome of numerical calculations; the 'true' elimination rate constant is underestimated by a factor of about 10 on average. Good correlation was found between our myoglobin estimates of 'infarct size' (using patient-mean kinetic constants), and independent estimates from serial serum CK-MB data, as calculated by the use of the method by Sobel et al.. Large inter-individual variations were found in the estimated infarct parameters, a circumstance which is of special interest in evaluation of therapeutic intervention studies on AMI-patients, and in infarct size prediction calculations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0036-5513
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-78
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Size estimation of acute myocardial infarction from serial serum myoglobin observations with due consideration of individual differences in basic kinetics.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't