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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1984-4-24
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00093,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00094,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00096,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00158,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00159,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00160,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00161,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00162,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00163,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00164,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00165,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00166,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00167,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00168,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00169,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00170,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00171,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00172,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00173,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00174,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00175,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00177,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00178,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J00179,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/K01239,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/K01890,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/K02544,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18047,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M19067,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X00423
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pubmed:abstractText |
Using S1 mapping and primer extension analysis, we have identified a number of human kappa-globin and beta-globin 5' RNA termini originating in the 200 bp upstream of the canonical mRNA cap sites. Upstream initiation sites have previously been reported for the human epsilon-globin gene (4,5) and the present work indicates that this is a general feature of the human beta-type globin genes. We have attempted to identify features common to such sites between the three genes. One site 170 bp upstream of the major beta-globin cap site and a site 1400 bp upstream of the major epsilon-globin cap site are located near putative PolIII promoter sequences and may therefore be transcribed by this enzyme. Alternative initiation sites located 200 bp and 50-100 bp upstream of the epsilon-globin and kappa-globin cap sites respectively are located within S1 hypersensitive regions of chromatin.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-218021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-277329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-390497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-497401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-597858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-6101195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-6154870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-6194893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-6194897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-6252349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-6269751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-6275357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-6292831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-6299573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-6310525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-6791577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-884738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-922889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6701091-978727
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1811-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6701091-Base Composition,
pubmed-meshheading:6701091-Base Sequence,
pubmed-meshheading:6701091-Chromatin,
pubmed-meshheading:6701091-Genes,
pubmed-meshheading:6701091-Globins,
pubmed-meshheading:6701091-Humans,
pubmed-meshheading:6701091-Nucleic Acid Hybridization,
pubmed-meshheading:6701091-Operon,
pubmed-meshheading:6701091-RNA, Messenger,
pubmed-meshheading:6701091-Transcription, Genetic
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pubmed:year |
1984
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pubmed:articleTitle |
Alternative sites of transcription initiation upstream of the canonical cap site in human gamma-globin and beta-globin genes.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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