Linked Life Data

6700600

Source:http://linkedlifedata.com/resource/pubmed/id/6700600

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-4-18
pubmed:abstractText
The purpose of this study was to provide a medical alternative to mastectomy in boys with excessive breast development. Eleven boys with bilateral gynecomastia, ranging in size between 9 X 7 cm and 3 X 3 cm in diameter, were treated with 200 mg of Danazol daily for 6 months. This therapy led to a reduction in breast size between 3 X 3 cm and 1,5 X 1,5 cm. The antigonadotropic action of Danazol was documented by inhibition of basal gonadotropin secretion, by disappearance of normal sleep dependent rhythms and by a reduced pituitary response to stimulation. Simultaneously, plasma testosteron secretion was suppressed without reduction of testicular volumes. In all patients the hypothalamo-pituitary gonadal axis normalized within 67 months after termination of therapy and no relapse was observed over a control period up to 26 months. The continuing regression after Danazol treatment emphasizes the effectiveness of drug therapy as an alternative regimen to surgical intervention.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0026-9298
pubmed:author
pubmed:issnType
Print
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
32-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
[Excessive gynecomastia in boys. Effective medical treatment using danazol (Winobanin)].
pubmed:publicationType
Journal Article, English Abstract