Linked Life Data

6699887

Source:http://linkedlifedata.com/resource/pubmed/id/6699887

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-4-24
pubmed:abstractText
[Cys(S-acetamidomethyl)1,8]angiotensin II has been synthesized by the solid-phase method and purified by carboxymethylcellulose chromatography and reversed-phase HPLC. Treatment of this peptide with iodine gave the cyclic octapeptide [Cys1,8]angiotensin II, which was isolated by Sephadex G-25 chromatography and reversed-phase HPLC. Comparison of the circular dichroism spectra of the open-chain and cyclic peptides, respectively, demonstrated the existence of a disulfide bond with right-handed chirality in the cyclic peptide. In the isolated rat uterus assay, the open-chain peptide was found to be a potent antagonist of angiotensin II, having approximately 10% of the activity of [Sar1, Ile8]angiotensin II, and the cyclic peptide had about 10% of the antagonist potency of its open-chain synthetic precursor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
404-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
A cyclic angiotensin antagonist: [1,8-cysteine]angiotensin II.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't