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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1984-4-24
|
| pubmed:abstractText |
The title compound was proposed to be a biologically active metabolite of a dopaminergic agent, 4-[2-(di-n-propylamino)ethyl]indole. This proposed metabolite was synthesized by a multistep sequence beginning with methyl 3,5-dinitro o-toluate, and involving the Batcho-Leimgruber modification of the Reissert indole synthesis. The target compound exhibited high potency/activity in vivo in a cat cardioaccelerator nerve assay and in vitro in an isolated cat atrium assay. It manifested maximal pharmacological effect less than 5 min after intravenous administration in cats, as compared with a 20-min lag time following intravenous administration of the nonoxygenated congener. These pharmacological data are consistent with the proposal that the target compound is a metabolite of 4-[2-(di-n-propylamino)ethyl]indole.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
386-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1984
|
| pubmed:articleTitle |
6-Hydroxy-4-[2-(di-n-propylamino)ethyl]indole: synthesis and dopaminergic actions.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|