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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1984-3-26
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pubmed:abstractText |
Honeybee and vespid venom-specific IgE were measured by RAST in randomly selected sera of 87 patients who had had anaphylactic reactions after insect stings. Overall there was a poor correlation between the titers of honeybee venom and yellow jacket or hornet venom-specific IgE. Sera from nine patients with high titers of both honeybee venom and yellow jacket venom-specific IgE were selected for RAST-inhibition studies, with these two venoms as coupling and inhibiting antigens. Three patterns of IgE-antibody specificity were detected. Four patients had unique antibody activity with no cross-reactivity between the yellow jacket and honeybee venom-specific IgE. This is probably the most common pattern in patients with dual sensitivity. Three patients reacted to a major allergen in yellow jacket venom cross-reacting with a minor allergen in honeybee venom. Their RAST-inhibition patterns demonstrated that the yellow jacket-venom RAST was inhibited by yellow jacket venom only and the honeybee-venom RAST was inhibited by both yellow jacket venom and honeybee venom. Two patients had the opposite pattern with honeybee-venom RAST inhibited by honeybee venom only and the yellow jacket RAST inhibited by both honeybee venom and yellow jacket venom. These latter patients reacted to a major allergen in honeybee venom that was cross-reacting with a minor allergen in yellow jacket venom. Studies with rabbit antisera raised to vespid and honeybee venoms demonstrated major antigens that were unique to each family that did not cross-react and several minor cross-reacting antigens.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
0091-6749
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
246-52
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6699307-Adolescent,
pubmed-meshheading:6699307-Adult,
pubmed-meshheading:6699307-Aged,
pubmed-meshheading:6699307-Bee Venoms,
pubmed-meshheading:6699307-Cross Reactions,
pubmed-meshheading:6699307-Desensitization, Immunologic,
pubmed-meshheading:6699307-Humans,
pubmed-meshheading:6699307-Hypersensitivity,
pubmed-meshheading:6699307-Immune Sera,
pubmed-meshheading:6699307-Immunoglobulin E,
pubmed-meshheading:6699307-Male,
pubmed-meshheading:6699307-Middle Aged,
pubmed-meshheading:6699307-Radioallergosorbent Test,
pubmed-meshheading:6699307-Wasp Venoms
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pubmed:year |
1984
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pubmed:articleTitle |
Studies of coexisting honeybee and vespid-venom sensitivity.
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pubmed:publicationType |
Journal Article,
Case Reports
|